EXPLORING THE ASSOCIATION BETWEEN BLOOD GROUP GENOTYPES AND COVID-19 DISEASE COURSE
DOI:
https://doi.org/10.5281/zenodo.15848909Keywords:
COVID-19; Kell; Duffy; Kidd; Blood group; Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP); Single Nucleotide Polymorphisms (SNPs).Abstract
Background: The novel Coronavirus disease 2019 (COVID-19) is one of the worst pandemics in recorded history and has greatly impacted the health, economy and social life of the entire world. Recent research has shown that the ABO blood group may influence the risk and severity of the SARSCOV-2 infection. Therefore, this study examines the association between severity to COVID-19 infection and the Kell, Duffy and Kidd blood groups/genotypes.
Methods: In this case-control study, the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method was used for determining the genotype of three blood groups (Kell, Duffy and, Kidd) in 100 patients with severe COVID-19 and 50 healthy controls.
Results: There were no significant differences in the genotype or allele distribution of Kell, Duffy and Kidd SNPs (rs8176058, rs12075 and rs1058396, respectively) between the severe COVID-19 and healthy control groups.
Conclusion: According to the result, different genotypes of Kell, Duffy and Kidd might not be risk factors for the severity of COVID-19.