DECIPHERING THE ROLE OF MMPS IN EXTRACELLULAR MATRIX DEGRADATION IN KASHIN-BECK DISEASE CARTILAGE

Abstract

Kashin-Beck disease (KBD) is a chronic osteochondrosis endemic to certain regions, notably in Russia and China, characterized by profound articular and epiphyseal cartilage damage. Chondrocyte necrosis, excessive apoptosis, and extracellular matrix degradation are hallmarks of KBD pathology. While various factors have been linked to chondrocyte injury in KBD, comprehensive understanding of underlying mechanisms remains elusive, hindering effective treatments. Matrix metalloproteinases (MMPs), a family of zinc-dependent proteins associated with extracellular matrix degradation, notably MMP-13, have been implicated in cartilage destruction. However, their precise role in KBD pathogenesis is not yet well-delineated. Recent findings suggest that the regulatory interaction of miR-488 with ZIP-8 can inhibit MMP-13 activity, fostering chondrocyte differentiation and cartilage recovery. MMP-13, a critical enzyme in cartilage degradation, primarily targets type II collagen. Unraveling the interplay between MMP-13 and other factors in KBD progression holds promise for more effective treatments and enhanced clinical management. Moreover, exploration of additional molecular and cellular mechanisms at play in KBD development is vital.