In Mexico, the rapid growth of tequila production has led to a substantial increase in agave utilization, resulting in a surge of agave bagasse, a lignocellulosic by-product. This study explores the potential agricultural applications of agave bagasse, which now accounts for a significant portion of agave processing residues. Over the last 6 years, the production of agave bagasse has risen significantly, aligning with the booming tequila industry and related agave-based products. Agave bagasse can be effectively integrated into plant growth substrates, offering numerous advantages over traditional soil cultivation. Common substrates in Mexico, such as coco coir, perlite, and vermiculite, facilitate higher strawberry yields, improved quality, and greater plant density. Substrate-based systems also promote environmental sustainability by reducing chemical usage and enabling the collection and disinfection of runoff water for reuse. Moreover, substrate cultivation allows growers to maintain consistent planting locations and respond swiftly to weather fluctuations. While substrate cultivation offers substantial benefits, it requires initial investments and a learning curve for growers to adapt to the technique and optimize fertilizer schedules. This study highlights the potential of utilizing agave bagasse in plant growth substrates as a sustainable and productive approach in the context of increasing agave production.