Earthquakes are recurrent and devastating natural disasters that result from a combination of natural and human factors. They often lead to the collapse of entire regions, endangering lives and causing significant damage to property. Areas prone to earthquakes are predominantly characterized by geological conditions comprising rock aggregates, making earthquake-induced landslides a prevalent and hazardous geological disaster. The complex composition of soil-rock mixed slopes complicates the understanding of their failure mechanisms, particularly in the context of earthquakes, where they pose a substantial threat to human safety. This research delves into the intricate and dynamic process of studying soil-rock mixed slopes under earthquake conditions. Employing the thermodynamic principle as its foundation, this study investigates the behavior of soil-rock mixed slopes during seismic events, offering a crucial technical framework for experimental endeavors while ensuring their feasibility. The research utilizes the FLAC3D program to construct a three-dimensional model, creating a virtual environment that facilitates in-depth experimentation. The simulation experiments with this three-dimensional model enhance the credibility of the collected data. Analyzing the destructive tendencies of soil-rock mixed slopes during earthquakes holds pivotal significance. By gaining insights into their behavior, this research contributes to landslide prevention, reduces the incidence of natural disasters, and lays the experimental groundwork for future investigations into earthquake-soil-rock mixed slopes.